Photochemically induced thrombosis combined with chronic restraint stress for modeling post-stroke depression in mice.

ABSTRACT:

Introduction

Post-stroke depression (PSD) is a prevalent neuropsychiatric disorder associated with impaired recovery in stroke survivors, potentially linked to dysregulation of brain-derived neurotrophic factor (BDNF). This study aimed to establish a novel animal model of PSD by integrating ischemic brain injury with chronic psychological stress.

Methods

Mice were subjected to photochemically induced thrombosis (PIT) to generate focal ischemic lesions in the parietal lobe, followed by chronic restraint stress (CRS) to simulate post-stroke psychological stress. Behavioral assessments (sucrose preference test, forced swim test, tail suspension test) and molecular analyses (BDNF, synaptophysin [SYP], interleukin-1 [IL-1], tumor necrosis factor-α [TNF-α]) were cond

SUBMITTER: Tuersunjiang T 

PROVIDER: S-EPMC11906474 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature