Intertumoral heterogeneity of the immune microenvironment in high grade canine mast cell tumors.

ABSTRACT:

Background

Canine cutaneous mast cell tumors (MCTs) are a common, yet clinically challenging tumor type given their variable biological behavior. Although patients with low grade MCTs can often be effectively managed with surgery alone, most dogs with high grade MCTs succumb to their disease despite multimodal therapy. An improved understanding of the immune tumor microenvironment (TME) may help identify novel prognostic and therapeutic targets.

Methods

In this study, we interrogated the immune transcriptional profiles of the TME in low and high grade MCTs, and quantified intratumoral T cells. Twelve client-owned dogs with MCTs (6 Kiupel low grade with clinically benign behavior and 6 Kiupel high grade with clinically aggressive behavior) that underwent curative-intent surge

SUBMITTER: Bardales KL 

PROVIDER: S-EPMC11906493 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature