Dog allergen-induced asthma in mice: a relevant model of T2^low severe asthma with airway remodelling.

ABSTRACT:

Objective and design

Airway remodelling (AR) is a disabling phenomenon in patients with severe asthma, yet suitable models are lacking. We previously developed a dog allergen-induced murine asthma model characterized by T2^low Th17-driven neutrophilic airway inflammation and AR. To assess its relevance to human AR associated with T2^low severe asthma, a condition characterised by poor response to inhaled steroids, we tested the steroid sensitivity of the key features of this model.

Material

Asthma was induced in C57BL/6 J mice by intranasal sensitization, followed by a three-week challenge with dog allergen.

Treatment

Daily intraperitoneal 1 mg kg^-1 dexamethasone was administrated during the last week of challenge.

Methods

We meas

SUBMITTER: Margelidon-Cozzolino V 

PROVIDER: S-EPMC11906515 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature