Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice.

ABSTRACT:

Introduction

Microplastics and nanoplastics are prevalent environmental contaminants. Recent reports indicate that polystyrene nanoparticles may adversely impact male reproductive health. This study aims to examine the effects of polystyrene exposure on sperm metabolism and the development of pre-implantation embryos.

Methods

In this study, male C57BL/6 mice were orally gavage-administered polystyrene nanoplastics (60 nm, 20 mg/kg/day) for 35 days to assess their impact on male reproduction and early embryonic development. Experiments included testicular transcriptome analysis, sperm metabolomics, sperm motility and fertilization assays, embryonic ROS detection, and RNA sequencing of 2-cell embryos, revealing the adverse effects of polystyrene exposure on sperm metabolism an

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11906707 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature