"Surviving and Thriving": evidence for cortical GABA stabilization in cognitively-intact oldest-old adults.

ABSTRACT: Age-related alterations in GABAergic function, including depletion of cortical GABA concentrations, is likely associated with declining cognitive performance in normative aging. However, the extent to which GABAergic function is perturbed in the highest-functioning stratum of the oldest-old (85+) population is unknown. For the first time, we report the stability of cortical GABA in this population. We extend our previously-reported Individual Participant Data Meta-Analysis of GABA levels across the lifespan, integrating four large cross-sectional datasets sampling cognitively-intact oldest-old adults. Within our lifespan model, the slope of age-related GABA differences in cognitively-intact oldest-old adults flattens after roughly age 80; within oldest-old adults only, inclusion of age doe

SUBMITTER: Britton MK 

PROVIDER: S-EPMC11906729 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature