Expression of tumor endothelial marker 1 in cardiac fibroblast contributes to atrial fibrosis in atrial fibrillation.

ABSTRACT: Atrial fibrosis is associated with atrial fibrillation (AF) and stroke. Tumor endothelial marker 1 (TEM1/CD248) is a transmembrane protein that appears in mesenchymal lineage-derived cells only during embryogenesis. Re-upregulation of TEM1 in fibroblasts plays an important role in organ fibrosis. We evaluated TEM1 expression in atrial fibrosis of AF patients and its physiological significance. Left atrial (LA) appendages were collected from 30 AF patients (mean age 64.0 years, 76.7% male) who underwent indicated cardiac surgery. Immunofluorescence staining showed TEM1 expression in the atrial cardiac fibroblasts in AF but not in normal atrial tissue. Western blot could detect TEM1 expression in the LA tissues of all 30 AF patients. There was a positive correlation between the levels of TEM

SUBMITTER: Li YH 

PROVIDER: S-EPMC11906773 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature