Metabolomics insights into the protective molecular mechanism of Vaccinium myrtillus against oxidative stress in intestinal cells.

ABSTRACT: Blueberry (Vaccinium myrtillus L.) is a rich source of secondary metabolites known for their potent antioxidant, anti-inflammatory, and cytoprotective properties. These compounds are essential in neutralizing reactive oxygen species (ROS), which are implicated in oxidative stress-related diseases. In this study, we induced oxidative stress in IEC-6 small intestine cells using hydrogen peroxide (H₂O₂), creating a cellular model to investigate the biochemical response. The obtained results showed that a blueberry extract (BLUBE) significantly exhibited strong antioxidant capacity, as evidenced by DPPH, FRAP and ABTS in vitro tests. Additionally, BLUBE effectively inhibited the release of reactive species in cells and enhanced cytoprotective response, as indicated by imp

SUBMITTER: Novi S 

PROVIDER: S-EPMC11906781 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature