Asymmetry in centrosome maturation revealed through AIR-1 dynamics in the early Caenorhabditis elegans embryo.

ABSTRACT: Centrosomes are critical organelles associated with the nucleus, consisting of a pair of centrioles surrounded by a cloud of pericentriolar material. They serve as key nucleation sites for microtubule arrays and are essential for positioning the nucleus prior to cell division, but mechanisms for ensuring proper centrosome positioning are not well understood. Previous research has identified asymmetries in microtubule arrays nucleated by centrosomes prior to cell division, including during the first cell cycle in Caenorhabditis elegans, as playing a critical role in centrosome positioning, however the origin of this asymmetry remains unclear. To explore potential sources of centrosome asymmetry, we developed a mathematical model of centrosome maturation, distinct from prior models by not pr

SUBMITTER: Plourde SM 

PROVIDER: S-EPMC11906807 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature