Intraoperative use of high-speed Raman spectroscopy during soft tissue sarcoma resection.

ABSTRACT: Retroperitoneal soft tissue sarcoma (RSTS) is a rare type of cancer with limited treatment options. Achieving complete resection with negative margins is one of the most significant prognostic factors for RSTS survival. The UltraProbe is a handheld point probe Raman spectroscopy system that significantly decreases the imaging time compared to the probe systems currently used. This study aims to determine the performance of the UltraProbe in detecting STS in an in vivo environment during their resection. Thirty patients were recruited at Maisonneuve-Rosemont Hospital, Montreal, Canada. Raman spectra were acquired during STS resection using the instrument. A machine learning random forest classification algorithm was developed to predict the diagnosis associated with new Raman spectra: STS o

SUBMITTER: Dulude JP 

PROVIDER: S-EPMC11906817 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature