Causal effect of the 25-Hydroxyvitamin D concentration on ocular diseases: A Mendelian randomization study.

ABSTRACT: Observational studies report controversial associations between vitamin D levels and ocular diseases. We investigated the potential causal effect of 25-hydroxyvitamin D [25(OH)D] on ocular diseases using two-sample Mendelian randomization (MR). We examined associations between 25(OH)D and various ocular diseases including age-related macular degeneration, cataracts, diabetic retinopathy, myopia, glaucoma, conjunctivitis, keratitis and optic neuritis. Data were from genome-wide association studies of 25(OH)D and ocular diseases. We performed MR analyses using inverse-variance weighted methods with sensitivity analyses. We found no significant causal relationships between 25(OH)D and ocular diseases (all P > 0.05). Tests for heterogeneity (P > 0.05) and pleiotropy (P > 0.05) supported the MR

SUBMITTER: Luo X 

PROVIDER: S-EPMC11906842 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature