Diffusion MRI with double diffusion encoding and variable mixing times disentangles water exchange from transient kurtosis.

ABSTRACT: Double diffusion encoding (DDE) makes diffusion MRI sensitive to a wide range of microstructural features, and the acquired data can be analysed using different approaches. Correlation tensor imaging (CTI) uses DDE to resolve three components of the diffusional kurtosis: isotropic, anisotropic, and microscopic kurtosis. The microscopic kurtosis is estimated from the contrast between single diffusion encoding (SDE) and parallel DDE signals at the same b-value. Another approach is multi-Gaussian exchange (MGE), which employs DDE to measure exchange. Sensitivity to exchange is obtained by contrasting SDE and DDE signals at the same b-value. CTI and MGE exploit the same signal contrast to quantify microscopic kurtosis and exchange, and this study investigates the interplay between these two qu

SUBMITTER: Chakwizira A 

PROVIDER: S-EPMC11906880 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature