Flexible hippocampal representation of abstract boundaries supports memory-guided choice.

ABSTRACT: Hippocampal cognitive maps encode the relative locations of spatial cues in an environment and adapt their representation when boundaries geometrically change. Hippocampal cognitive maps can represent abstract knowledge, yet it's unclear whether the hippocampus is sensitive to changes to the extreme coordinates, boundaries, of abstract spaces. We create a memory-guided choice task to test whether the human hippocampus and medial prefrontal cortex (mPFC) flexibly learn abstract boundary representations in distinct two-dimensional (2D) knowledge spaces. Participants build up a 2D map-like representation of abstract boundaries, where the hippocampus and mPFC represent a decision cue's Euclidean distance to the closest boundary. Notably, mPFC distance representations selectively reflect indivi

SUBMITTER: Esposito M 

PROVIDER: S-EPMC11906885 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature