Long-term impact of exposure to Royal Guard, a pyriproxyfen-based bed net, on pyrethroid-resistant malaria vectors from Cameroon using DNA-based metabolic resistance markers.

ABSTRACT:

Background

Escalating pyrethroid resistance in malaria vectors highlights the urgency of implementing new control tools incorporating non-pyrethroid molecules. Here, using DNA-based metabolic resistance markers, we assessed the efficacy of the dual active ingredients net Royal Guard against pyrethroids-resistant malaria vectors in Cameroon, establishing its long-term impact on mosquitoes' life traits after exposure.

Results

Cone assays revealed low efficacy of Royal Guard against field Anopheles populations. However, analysis of the survival curves revealed that unexposed mosquitoes lived longer (11.4 ± 0.4 days) than those exposed to Royal Guard (7.9 ± 0.2 days) (χ² = 6; P = 0.05), indicating that despite the lower immediate mortality observed against resistant m

SUBMITTER: Ngongang-Yipmo ES 

PROVIDER: S-EPMC11906912 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature