Lipid oxidation in young patients with newly diagnosed bipolar disorder and their relatives.

ABSTRACT:

Background

Oxidative stress may be involved in the pathophysiology of bipolar disorder (BD). Malondialdehyde (MDA), a product of fatty acid peroxidation has been proposed as a trait marker of BD associated with familial risk. However, little is known about MDA levels in young patients newly diagnosed with BD and their unaffected first-degree relatives (UR).

Methods

In this substudy of the ongoing longitudinal "Bipolar Illness Onset study", we included baseline data and first, we compared fasting blood MDA levels in 130 young patients aged 15-25 years newly diagnosed with BD, 57 UR, and 88 healthy control individuals (HC). Second, we investigated associations between levels of MDA and illness variables in patients with BD. Third, we investigated associations between MDA level

SUBMITTER: Stanislaus S 

PROVIDER: S-EPMC11906955 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature