Gait and balance worsening after bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson's disease: a systematic review.

ABSTRACT:

Background

Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a widely applied therapy in Parkinson's disease (PD). Occasionally, postoperative worsening of gait or balance occurs, even in the face of a persistently gratifying appendicular symptom improvement. The characteristics vary considerably, and the risk factors for this postoperative gait or balance worsening are largely unknown. We systematically investigated the literature for all cases of gait or balance worsening after STN-DBS in PD and explored its characteristics and determinants. In consecutive populations with best medical treatment as the control group, we also explored its incidence.

Methods

We searched PubMed, Embase and Cochrane. We considered all cases occurring between 1 month after surgery

SUBMITTER: Janssen Daalen JM 

PROVIDER: S-EPMC11907047 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature