Psychological distress following multi-gene panel testing for hereditary breast and ovarian cancer risk.

ABSTRACT: Advances in our understanding of the genetic landscape of hereditary breast and ovarian cancer (HBOC) have led to the clinical adoption of multi-gene panel testing. Panel testing introduces new sources of genetic uncertainty secondary to the inclusion of moderate- and low-penetrance genes, as well as the increased likelihood of identifying a variant of uncertain significance (VUS). This cross-sectional study explored the post-test psychological functioning of women who underwent multi-gene panel testing for HBOC susceptibility genes. Two hundred and ninety-five women who underwent panel testing within the previous 2 years completed a study questionnaire to measure levels of cancer-related and genetic testing-related distress using the Impact of Events Scale (IES) and the Multidimensional I

SUBMITTER: Carlsson L 

PROVIDER: S-EPMC11907178 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature