Developing Microelectrode Arrays for the Point-of-Care Multiplex Detection of Metabolites.

ABSTRACT: DNA-aptamer-functionalized electrode arrays can provide an intriguing method for detecting pathogen-derived exometabolites. This work addresses the limitations of previous aptamer-based pathogen detection methods by introducing a novel surface design that bridges the gap between initial efforts in this area and the demands of a point-of-care device. Specifically, the use of a diblock copolymer coating on a high-density microelectrode array and Cu-mediated cross coupling reactions that allow for the exclusive functionalization of that coating by any electrode or set of electrodes in the array provides a device that is stable for 1 year and compatible with the multiplex detection of small-molecule targets. The new chemistry developed allows one to take advantage of a large number of electrod

SUBMITTER: Chang YC 

PROVIDER: S-EPMC11907268 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature