Leveraging microtopography to pattern multi-oriented muscle actuators.

ABSTRACT: Engineering skeletal muscle tissue with precisely defined alignment is of significant importance for applications ranging from drug screening to biohybrid robotics. Aligning 2D contractile muscle monolayers, which are compatible with high-content imaging and can be deployed in planar soft robots, typically requires micropatterned cues. However, current protocols for integrating microscale topographical features in extracellular matrix hydrogels require expensive microfabrication equipment and multi-step procedures involving error-prone manual handling steps. To address this challenge, we present STAMP (simple templating of actuators via micro-topographical patterning), an easily accessible and cost-effective one-step method to pattern microtopography of various sizes and configurati

SUBMITTER: Rossy T 

PROVIDER: S-EPMC11907412 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature