HMGN2 accelerates the proliferation and cell cycle progression of glioblastoma by regulating CDC20 expression.

ABSTRACT: Gliomas represent the most common primary malignant intracranial tumors in adults. Despite recent advances in treatment, the prognosis of patients with glioblastoma remains poor. Epigenetic abnormalities, the hallmarks of various types of cancer, contribute to the dysregulated expression of cancer-related genes. Post-translational modification of histones plays a pivotal role in cancer development and progression by modulating gene transcription, chromatin remodeling, and nuclear structure. Therefore, further exploration of the molecular mechanisms of epigenetic regulation in gliomas and the identification of superior therapeutic targets are required. High-mobility group nucleosomal-binding domain 2 (HMGN2) participates in the epigenetic regulation of genes through histone modification and

SUBMITTER: Zhong J 

PROVIDER: S-EPMC11907455 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature