A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease.

ABSTRACT:

Background

This single-arm study evaluates the feasibility, safety, and preliminary effects of two senolytic agents, Dasatinib and Quercetin (DQ), in older adults at risk of Alzheimer's disease.

Methods

Participants took 100 mg of Dasatinib and 1250 mg of Quercetin for two days every two weeks over 12 weeks. Recruitment rate, adverse events, absolute changes in functional outcomes, and percent changes in biomarkers were calculated. Spearman correlations between functional and biomarker outcomes were performed.

Findings

Approximately 10% of telephone-screened individuals completed the intervention (n = 12). There were no serious adverse events related to the intervention. Mean Montreal Cognitive Assessment (MoCA) scores non-significantly increased following DQ by 1.0 p

SUBMITTER: Millar CL 

PROVIDER: S-EPMC11907475 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature