Failure of intravenous flumazenil to antagonize alfaxalone anesthesia in cats.

ABSTRACT: ObjectivesThe aim of the present study was to assess the gamma-aminobutyric acid type A (GABA_A) receptor antagonist flumazenil and its effect on the anesthetic activity of the GABA_A receptor agonist alfaxalone when administered intravenously in cats.MethodsA prospective, randomized, blinded, two-period two-treatment crossover study was conducted. Eight (six male, two female) healthy adult neutered cats, 4.5-7.0 kg body weight, owned by IndyVet Emergency and Specialty Hospital were enrolled. Cats were randomly assigned to one of two treatment groups, flumazenil or saline (period 1). During period 2, cats were administered the opposite treatment. Treatment was either 0.1 mg/kg flumazenil or an equal volume of 0.9% sodium chloride. Before treatment, a published, abbrevia

SUBMITTER: Kloft HM 

PROVIDER: S-EPMC11907522 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature