Molecular heterogeneity in human stroke - What can we learn from the peripheral blood transcriptome?

ABSTRACT: Stroke is a multifaceted disease with genetic and environmental components like diet and lifestyle. The central nervous and immune systems display complex interactions, with the peripheral immune response participating in brain injury and repair mechanisms following stroke. The bidirectional communication between the injured brain and peripheral blood presents an opportunity to investigate the molecular changes in the latter. There is substantial heterogeneity in stroke pathogenesis, pathophysiology, comorbidities, and response to treatment and outcome. This is captured and underscored by heterogeneity in the peripheral blood transcriptome. The current review highlights the role of the human peripheral blood transcriptome architecture for molecular phenotyping of different stroke etiologie

SUBMITTER: Stamova B 

PROVIDER: S-EPMC11907527 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature