Current Best Evidence for 5 Promising Medications Used for Scar Minimization Therapy.

ABSTRACT: Introduction: Wound healing by fibrosis allows for closure of a wound, but leaves behind a permanent scar with physical and psychological effects. The primary aim of this narrative review was to summarize the current status of the evidence supporting the use of oral or topical medications to minimize scarring in humans. Methods: With the help of a health sciences librarian, PubMed, Embase, and Scopus were searched up to March 31, 2023, to investigate potential medications to ameliorate scarring. Based on this search, the medications pirfenidone, losartan, trichostatin A, enalapril, and atorvastatin were identified as 5 therapies with the most research to support their use. Studies discussing noncutaneous scarring (myocardial, intraabdominal, etc) or in animal models were excl

SUBMITTER: Dua N 

PROVIDER: S-EPMC11907609 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature