Two possible hemodynamic mechanisms underlying the growth of cerebral aneurysms depending on their size: The NHO CFD ABO study.

ABSTRACT: Cerebral aneurysm rupture has a poor prognosis, and growing aneurysms are prone to rupture. We therefore conducted a prospective observational study to clarify hemodynamics inducing aneurysm growth, which are poorly understood. Computational fluid dynamics analysis was performed using the patient-specific arterial geometry and flow velocities. Hemodynamic metrics were compared by multivariate analysis between aneurysms enlarged ≥1 mm and stable aneurysms. We enrolled 481 patients. For aneurysms <4 mm, the time-averaged wall shear stress (WSS) was significantly higher in growing aneurysms for the whole aneurysm, neck, body and parent artery, and transverse WSS was significantly higher on the neck and parent artery. In aneurysms ≥4 mm, the normalized transverse WSS was significantly higher i

SUBMITTER: Fukuda S 

PROVIDER: S-EPMC11907627 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature