Psychotic-Spectrum Disorders With Comorbid Anxiety Are Predisposing Factors for Parkinson's Disease in a Case-Control Study.

ABSTRACT:

Background

Multiple studies have demonstrated associations between psychiatric conditions and Parkinson's disease (PD) development; fewer have examined psychotic-spectrum disorders and PD development.

Objective

The objective was to assess the prevalence of psychotic-spectrum disorders with and without depression and anxiety preceding a PD diagnosis.

Methods

In this retrospective, case-control study of adults > 60 years of age, cases were identified by PD diagnosis and controls were identified in a 3:1 ratio by ambulatory encounter from 2015 to 2020. Psychiatric conditions were identified by diagnosis code up to 5 years prior to the index date. Conditional logistic regression was conducted to assess associations.

Results

Among 13,998 patients, the odds of PD wer

SUBMITTER: Shvartsur A 

PROVIDER: S-EPMC11907661 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature