Single nucleotide polymorphisms in ovarian cancer impacting lipid metabolism and prognosis: an integrated TCGA database analysis.

ABSTRACT: Ovarian cancer (OC) stands as a formidable adversary among women, remaining a leading cause of cancer-related mortality owing to its aggressive and invasive nature. Investigating prognostic markers intricately linked to OC's molecular pathogenesis represents a critical avenue for enhancing patient outcomes and survival prospects. In this comprehensive study, we embarked on a bioinformatics journey, leveraging the vast repository of single nucleotide polymorphism (SNP) data from OC patients available within the TCGA database. Our overarching goal was to unearth the genetic underpinnings of OC, shedding light on potential prognostic markers that could significantly impact clinical decision-making and patient care. Our meticulous analysis led to the discovery of five mutated genes-APOB, BRCA1

SUBMITTER: Wang H 

PROVIDER: S-EPMC11907782 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature