The role of urinary microbiota in primary and recurrent bladder cancer: insights from a propensity score matching study.

ABSTRACT:

Background

Bladder cancer (BCa) is a common urinary malignancy with high recurrence rates in non-muscle invasive bladder cancer (NMIBC), posing significant clinical challenges. Emerging evidence links urinary microbiota to cancer progression; however, their role in BCa recurrence remains unclear. This study aimed to explore urinary microbiota differences between primary and recurrent BCa to identify potential microbiological markers and mechanisms associated with recurrence.

Methods

Urine samples were collected from 170 BCa patients, including 125 with primary Bca(BCa_P) and 45 with recurrent BCa (BCa_R). All samples underwent 16 S rRNA gene sequencing, and clinical data were collected, including age, sex, body mass index (BMI), smoking history, pathological grade, and other

SUBMITTER: Sheng Z 

PROVIDER: S-EPMC11907829 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature