Small extracellular vesicles from young adipose-derived stem cells ameliorate age-related changes in the heart of old mice.

ABSTRACT:

Background

Aging entails a progressive decline in physiological functions, elevating the risk of age-related diseases like heart failure or aortic stenosis. Stem cell therapies, especially those that use paracrine signaling, can potentially mitigate the adverse effects of aging.

Objectives

The objective is to explore the potential of small extracellular vesicles (sEVs) derived from young adipose-derived stem cells (ADSC-sEVs) in reversing structural, molecular, and functional changes associated with aging in the heart.

Methods

Aged C57BL/6J mice were treated intravenously with ADSC-sEVs from young mice or PBS as controls. Young mice were included to identify specific age-associated changes. The impact of sEV treatment on cardiac function was assessed using transthorac

SUBMITTER: Sanz-Ros J 

PROVIDER: S-EPMC11907833 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature