Intratumoral and peritumoral CT radiomics in predicting anaplastic lymphoma kinase mutations and survival in patients with lung adenocarcinoma: a multicenter study.

ABSTRACT:

Background

To explore the value of intratumoral and peritumoral radiomics in preoperative prediction of anaplastic lymphoma kinase (ALK) mutation status and survival in patients with lung adenocarcinoma.

Methods

We retrospectively collected data from 505 eligible patients with lung adenocarcinoma from four hospitals (training and external validation sets 1-3). The CT-based radiomics features were extracted separately from the gross tumor volume (GTV) and GTV incorporating peritumoral 3-, 6-, 9-, 12-, and 15-mm regions (GPTV₃, GPTV₆, GPTV₉, GPTV₁₂, and GPTV₁₅), and screened the most relevant features to construct radiomics models to predict ALK (+). The combined model incorporated radiomics scores (Rad-scores) of the best

SUBMITTER: Chen W 

PROVIDER: S-EPMC11907895 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature