The global, regional, and national burdens of maternal sepsis and other maternal infections and trends from 1990 to 2021 and future trend predictions: results from the Global Burden of Disease study 2021.

ABSTRACT:

Background

Maternal sepsis and other maternal infections (MSMIs) significantly contribute to maternal morbidity and mortality worldwide, posing critical challenges due to their rapid progression and severe outcomes.

Methods

Data from the Global Burden of Disease (GBD) 2021 study, covering 204 countries and territories, were used to evaluate the incidence, death, and disability-adjusted life years (DALYs) of MSMI. Statistical methods included joinpoint regression, age-period-cohort analysis, decomposition analysis, frontier analysis, and ARIMA model forecasting.

Results

From 1990 to 2021, global MSMI incidence decreased from 22.45 million to 19.05 million, with the age-standardized rate (ASR) dropping from 764.03 (95% UI: 573.01-970.54) to 494.19 (95% UI: 377.34-623.90

SUBMITTER: Hu Q 

PROVIDER: S-EPMC11907898 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature