MiR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway.

ABSTRACT:

Purpose

Polycystic ovary syndrome (PCOS) is currently recognized as a condition that affects several systems in the body, including the reproductive, endocrine, and cardiovascular systems. Prevalent among teenagers and women of reproductive age. Prior research has demonstrated an elevation of miR-34a-5p within the follicular fluid (FF) of women of PCOS. Despite this, the precise mechanisms through which miR-34a-5p influences granulosa cells (GC) development and function remain poorly characterized.

Methods

Therefore, this study investigates the involvement and pathogenic mechanisms of miR-34a-5p within GCs in the context of PCOS. The human granulosa-like tumor cell line (KGN) got transfected at a control, as well as a miR-34a-5p mimic and inhibitor, respectively. Monitor cel

SUBMITTER: Zhang K 

PROVIDER: S-EPMC11907913 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature