Antimicrobial strategies of lower respiratory tract infections in immunocompromised patients based on metagenomic next-generation sequencing: a retrospective study.

ABSTRACT:

Background

Immunocompromised patients with Lower Respiratory Tract Infections (LRTI) frequently encounter a diverse range of pathogenic infections, characterized by rapid disease progression and significant mortality rates due to reckless or excessive utilization of antibiotics. Therefore, it is crucial to promptly and accurately identify the causative microorganisms for pathogen diagnosis and clinical decision-making. The objective of this study is to evaluate the clinical applicability of metagenomic next-generation sequencing (mNGS) in the diagnosis and management of LRTI, as well as its impact on empirical antibacterial therapy for patients with varying immune statuses.

Methods

We conducted a comparative analysis of positivity rate, detection accuracy, pathogen spectrum,

SUBMITTER: Meng B 

PROVIDER: S-EPMC11907972 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature