Lactate infusion improves cardiac function in a porcine model of ischemic cardiogenic shock.

ABSTRACT:

Background

Cardiogenic shock (CS) is associated with high mortality and medical therapies have failed to improve survival. Treatment with lactate is associated with improved cardiac function which may benefit this condition. Comprehensive hemodynamic assessment of lactate administration in CS is lacking, and the mechanisms underlying the cardiovascular effects of lactate in CS have not yet been elucidated. In this study we aimed to study the cardiovascular and cardiometabolic effects of treatment with lactate in experimental ischemic CS.

Methods

In a randomized, blinded design, 20 female pigs (60 kg) were studied. Left main coronary artery microsphere injections were used to cause CS, defined as a 30% reduction in CO or mixed venous saturation (SvO₂). Subjects wer

SUBMITTER: Horsdal OK 

PROVIDER: S-EPMC11907994 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature