Reduced risks of influenza-associated hospitalization and complications following vaccination among over 2 million older individuals: a nationwide study using target trial emulation framework.

ABSTRACT:

Background

Current evidence on influenza vaccine effectiveness (VE), which is predominately derived from small high-risk older populations and focuses on specific influenza-related complications, might not be generalizable to real-world older populations with diverse characteristics in Taiwan. Therefore, this observational study with a target trial emulation framework aimed to evaluate the clinical effectiveness of an influenza vaccine on influenza infection, complications, and associated healthcare utilization and costs.

Methods

1,214,392 propensity-score-matched pairs of vaccinated and unvaccinated older populations from the influenza season of 2018/2019 were identified from Taiwan's National Health Insurance Research Database. VE (estimated as 1 minus hazard ratio [HR]*10

SUBMITTER: Peng ZY 

PROVIDER: S-EPMC11907999 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature