Association of a 7.9 kb Endogenous Retrovirus Insertion in Intron 1 of CD36 with Obesity and Fat Measurements in Sheep.

ABSTRACT:

Background

Endogenous retroviruses (ERVs) enhance genetic diversity in vertebrates, including sheep. This study investigates the role of Ov-ERV-R13-CD36 within CD36 gene and its association with phenotypic traits in sheep. Analyzing 58 sheep genomes revealed that ERVs constitute approximately 6.02% to 10.05% of the genomic content. We identified 31 retroviral insertion polymorphisms (RIPs) from 28 ERV groups. Among these, Ov-ERV-R13-CD36, which is specifically classified as a beta retrovirus, was selected for further analysis due to its location in CD36 gene, known for its role in fat metabolism, obesity (OB), body weight (BW), and body condition score (BCS). We assessed the association of Ov-ERV-R13-CD36 with OB and BCS across six sheep breeds, utilizing data from 1,355 individual

SUBMITTER: Saleh AA 

PROVIDER: S-EPMC11908002 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature