Effects of antenatal corticosteroid therapy in animal models of fetal growth restriction: a systematic review and meta-analysis.

ABSTRACT:

Background

Antenatal corticosteroids (CCS) reduce the risks of neonatal morbidity and mortality following spontaneous preterm birth. It is however debated whether effects of antenatal CCS hold for pregnancies complicated by fetal growth restriction (FGR) at risk for preterm birth. This study aimed to summarize effects of antenatal CCS in animal models of FGR by performing a systematic review and meta-analysis.

Methods

The protocol for this systematic review was registered prospectively at PROSPERO (CRD42022318861). A systematic search was performed in PubMed and Embase from inception to April 5th 2023. Animal studies reporting on effects of antenatal CCS compared to placebo or non-treatment in FGR and appropriately grown offspring were included. Primary outcomes were fetal o

SUBMITTER: van de Meent M 

PROVIDER: S-EPMC11908052 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature