Diurnal oscillations of amino acids dynamically associate with microbiota and resistome in the colon of pigs.

ABSTRACT:

Background

Nutrients are one of the key determinants of gut microbiota variation. However, the intricate associations between the amino acid (AA) profile and the dynamic fluctuations in the gut microbiota and resistome remain incompletely elucidated. Herein, we investigated the temporal dynamics of AA profile and gut microbiota in the colon of pigs over a 24-hour period, and further explored the dynamic interrelationships among AA profile, microbiota, and resistome using metagenomics and metabolomics approaches.

Results

JTK_circle analysis revealed that both the AA profile and the gut microbiota exhibited rhythmic fluctuations. With respect to the feed intake, all AAs except L-homoserine (P_Adj = 0.553) demonstrated significant fluctuations. Over 50% of Lactobacill

SUBMITTER: Wang H 

PROVIDER: S-EPMC11908058 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature