Differences in plasma metabolome between non-Hispanic White and non-Hispanic Black women.

ABSTRACT:

Background

To understand potential racial differences in disease susceptibility and develop targeted prevention strategies, it is essential to establish biological differences between racial groups in healthy individuals. However, knowledge about how race impacts metabolites is limited. We therefore performed a cross-sectional study using comprehensive metabolomics analysis to investigate racial differences in metabolites among 506 non-Hispanic White (NHW) women and 163 non-Hispanic Black (NHB) women.

Methods

We performed untargeted plasma metabolomic profiling using Metabolon's platform (Durham, NC®) and identified 1074 metabolites in 9 super-pathways. We used multivariable linear regression models, adjusted for confounders, to identify associations between race and metabol

SUBMITTER: Pourali G 

PROVIDER: S-EPMC11908082 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature