Meta-Analysis: Inverse Association Between Helicobacter pylori Infection and Eosinophilic Oesophagitis.

ABSTRACT:

Background

Exposure to Helicobacter pylori (H. pylori) has been associated with a decreased risk of eosinophilic oesophagitis (EoE).

Aim

The aim of this study is to determine the association between H. pylori infection and EoE in this updated meta-analysis.

Methods

We searched MEDLINE, Scopus and ISI Web of Science, through to November 2024. We included studies reporting the status of H. pylori infection in patients with and without EoE or oesophageal eosinophilia (EE). We used a random-effects model to pool estimates.

Results

We analysed 19 studies including 1.704.821 subjects. H. pylori infection was associated with a 46% lower risk of EoE/EE (OR: 0.54, 95% CI 0.43 to 0.67). Comparable findings were observed when subgrouping studies by location or design. The

SUBMITTER: Spinelli I 

PROVIDER: S-EPMC11908113 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature