Accurate prediction of thermoresponsive phase behavior of disordered proteins.

ABSTRACT: Protein responses to environmental stress, particularly temperature fluctuations, have long been a subject of investigation, with a focus on how proteins maintain homeostasis and exhibit thermoresponsive properties. While UCST-type (upper critical solution temperature) phase behavior has been studied extensively and can now be predicted reliably using computational models, LCST-type (lower critical solution temperature) phase transitions remain less explored, with a lack of computational models capable of accurate prediction. This gap limits our ability to probe fully how proteins undergo phase transitions in response to temperature changes. Here, we introduce Mpipi-T, a residue-level coarse-grained model designed to predict LCST-type phase behavior of proteins. Parametrized using both ato

SUBMITTER: Chakravarti A 

PROVIDER: S-EPMC11908177 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature