Decoding neuronal wiring by joint inference of cell identity and synaptic connectivity.

ABSTRACT: Animal behaviors are executed by motor neurons (MNs), which receive information from complex pre-motor neuron (preMN) circuits and output commands to muscles. How motor circuits are established during development remains an important unsolved problem in neuroscience. Here we focus on the development of the motor circuits that control the movements of the adult legs in Drosophila melanogaster. After generating single-cell RNA sequencing (scRNAseq) datasets for leg MNs at multiple time points, we describe the time course of gene expression for multiple gene families. This analysis reveals that transcription factors (TFs) and cell adhesion molecules (CAMs) appear to drive the molecular diversity between individual MNs. In parallel, we introduce ConnectionMiner, a novel computational to

SUBMITTER: Gupta HP 

PROVIDER: S-EPMC11908227 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature