Overlap of high-risk individuals across family history, genetic & non-genetic breast cancer risk models: Analysis of 180,398 women from European & Asian ancestries.

ABSTRACT:

Background

Breast cancer is multifactorial. Focusing on limited risk factors may miss high-risk individuals.

Methods

We assessed the performance and overlap of various risk factors in identifying high-risk individuals for invasive breast cancer (BrCa) and ductal carcinoma in situ (DCIS) in 161,849 European-ancestry and 18,549 Asian-ancestry women. Discriminatory ability was evaluated using the area under the receiver operating characteristic curve (AUC). High-risk criteria included: 5-year absolute risk ≥1·66% by the Gail model [GAIL_binary]; first-degree family history of breast cancer [FH_binary]; 5-year absolute risk ≥1·66% by a 313-variants polygenic risk score [PRS_binary]; and carriers of pathogenic variants in breast cancer predisposition

SUBMITTER: Ho PJ 

PROVIDER: S-EPMC11908272 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature