Heme Detoxification in the Malaria Parasite <i>Plasmodium falciparum</i>: A Time-Dependent Basal-Level Analysis.

ABSTRACT: Malaria is a deadly disease for which therapeutic options are threatened by the rise of antimalarial resistance. Inhibiting the formation of hemozoin (the product of heme detoxification) in the digestive vacuole (DV) is the mechanism of action of numerous antimalarial drugs, including those in development as new therapies. This drug target remains attractive as hemozoin is an abiotic and non-mutable molecule, unique to the parasite. The underlying parasite biology of the heme detoxification pathway is complex and requires a deeper understanding. This study focuses on the DV of Plasmodium falciparum, utilizing confocal microscopy, immunoblotting and cellular fractionation techniques to study its native state over time. Using parameters such as the uptake into and growth of the DV, re

SUBMITTER: Garnie LF 

PROVIDER: S-EPMC11908274 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature