Acute biomarkers of consciousness are associated with recovery after severe traumatic brain injury.

ABSTRACT:

Objective

Determine whether acute behavioral, electroencephalography (EEG), and functional MRI (fMRI) biomarkers of consciousness are associated with outcome after severe traumatic brain injury (TBI).

Methods

Patients with acute severe TBI admitted consecutively to the intensive care unit (ICU) participated in a multimodal battery assessing behavioral level of consciousness (Coma Recovery Scale-Revised [CRS-R]), cognitive motor dissociation (CMD; task-based EEG and fMRI), covert cortical processing (CCP; stimulus-based EEG and fMRI), and default mode network connectivity (DMN; resting-state fMRI). The primary outcome was 6-month Disability Rating Scale (DRS) total scores.

Results

We enrolled 55 patients with acute severe TBI. Six-month outcome was available in 45 (45.

SUBMITTER: Bodien YG 

PROVIDER: S-EPMC11908294 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature