Stimulation-related increases in power spectral density covary with clinical evidence of overstimulation during deep brain stimulation for pediatric dystonia.

ABSTRACT:

Background

Dystonia patients undergoing deep brain stimulation (DBS) often require individualized stimulation settings. While effective settings reduce dystonia, excessive stimulation can worsen symptoms. Assessing DBS effects during office visits is challenging, as clinical changes can be delayed hours to days.

Objectives

We evaluated whether local field potentials (LFPs) could serve as an acute biomarker of excessive stimulation in dystonia patients.

Methods

Real-time LFP band power and dystonia severity were quantified and compared during sequential changes in stimulation amplitude.

Results

Dystonia worsening was temporally associated with clinically evident and statistically significant increases in LFP band power during in-office DBS programming sessions.<

SUBMITTER: Pascual M 

PROVIDER: S-EPMC11908308 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature