Offspring genetic diversity regulates rearing experiences that predict differential susceptibility to <i>Chd8</i> haploinsufficiency.

ABSTRACT: Mouse models of human disease focus on determining the direct impact of genetic mutations on phenotypes related to clinical presentations. For example, loss of function mutations in the autism-associated CHD8 gene is highly penetrant for trait and behavioral abnormalities in children, but there is substantial clinical heterogeneity in the occurrence and extent of disruptions between individuals. Using a large genetic reference panel of mice, we recently showed that genetic background strongly regulates variability in trait disruptions caused by Chd8 haploinsufficiency. Here, we hypothesized that genetics could also impact the variability in response to early life experiences, thus contributing to differential susceptibility to neurodevelopmental disorders. To examine how gene

SUBMITTER: Tabbaa M 

PROVIDER: S-EPMC11908356 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature