Magnetic resonance imaging to detect tumor hypoxia in brain malignant disease: A systematic review of validation studies.

ABSTRACT: Tumor hypoxia indicates a worse prognosis in brain malignancies; however, current gold-standard methods for assessing tumor hypoxia are invasive and often inaccessible. Magnetic Resonance Imaging (MRI) is widely available, but its validity for identifying tumor hypoxia or hypoxia-related neoangiogenesis is not well characterized. A systematic literature search was performed across PubMed and Embase Databases. The search query identified MRI studies that validated hypoxia-surrogate imaging sequences against gold-standard hypoxia or neoangiogenesis detection methods in patients with brain malignancies. Literature screen identified 23 manuscripts published between 2007 and 2022. Among conventional MRI sequences, peritumoral edema and signal change after contrast administration were associated

SUBMITTER: Bai Y 

PROVIDER: S-EPMC11908384 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature