Late-Onset Sepsis Among Extremely Preterm Infants During the COVID-19 Pandemic.

ABSTRACT:

Objectives

To compare incidence of late-onset sepsis (LOS) among extremely preterm infants before and during the COVID-19 pandemic.

Methods

Multicenter cohort study of infants with birthweight 401 to 1000 g or gestational age 22 to 28 weeks. LOS was defined as a bacterial or fungal pathogen isolated from blood or cerebrospinal fluid culture obtained after 72 hours of age. Primary outcome was LOS incidence calculated as incidence proportion (LOS cases among all admissions) and incidence rate (LOS events/1000 patient days). A multivariable Poisson regression model was used to compare the adjusted risk of LOS incidence proportion before (1/1/18-3/31/20) and during the pandemic (4/1/20-12/31/21). An interrupted time series analysis using a generalized linear mixed model with cen

SUBMITTER: Mukhopadhyay S 

PROVIDER: S-EPMC11908436 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature