Systolic and diastolic dysfunction is exacerbated by age and spinal cord injury in male and female mice with central nervous system serotonin deficiency.

ABSTRACT: The present study was designed to explore whether the depletion of serotonin (5-HT) in the central nervous system (CNS^5-HT) leads to systolic and diastolic dysfunction and whether this dysfunction is exacerbated by sex, age and spinal cord injury. Echocardiographic assessment of systolic and diastolic function was completed in young and old male and female tryptophan hydroxylase 2 knockout (TPH2^-/-) and wild-type (TPH2^+/+) mice with intact spinal cords, as well as in C₂  spinal cord hemisected young TPH2^-/- and TPH2^+/+ mice. In addition, lumbar sympathetic nervous system activity was recorded in elderly male and female intact TPH2^-/- and TPH2^+/+ mice. Systolic and diastolic dysfunction was evident in yo

SUBMITTER: Qiu Q 

PROVIDER: S-EPMC11908478 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature