Mitochondrial efficiency in resting skeletal muscle in vivo: a novel non-invasive approach using multinuclear magnetic resonance spectroscopy in humans.

ABSTRACT: Mitochondrial efficiency is a critical metabolic parameter with far-reaching implications for tissue homeostasis. However, the direct measurement of oxygen consumption (VO₂) and ATP production from a large tissue sample in vivo remains challenging. Using phosphorus (³¹P) and proton (¹H) magnetic resonance spectroscopy (MRS), this study aimed to non-invasively quantify the skeletal muscle ATP synthesis rate and VO₂ to determine mitochondrial efficiency at rest and during muscle contraction in humans. We assessed mitochondrial efficiency in the plantar flexor muscles of 12 healthy adults (21 ± 1 years) using ³¹P and ¹H MRS within a 3T MR system. MRS data were acquired at rest and during constant workloads to quantify oxidative

SUBMITTER: Erol ME 

PROVIDER: S-EPMC11908483 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature